PRECLINICAL PUBLICATION · 2019

XQ-1H alleviates cerebral ischemia in mice through inhibition of apoptosis and promotion of neurogenesis in a Wnt/beta-catenin signaling dependent way.

Mouse / Ischaemia-reperfusion

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

XQ-1H (10-O-(N,N-dimethylaminoethyl)-ginkgolide B methanesulfonate)

PMID 31499069 ↗2019Reported benefit

XQ-1H alleviates cerebral ischemia in mice through inhibition of apoptosis and promotion of neurogenesis in a Wnt/beta-catenin signaling dependent way.

MouseIschaemia-reperfusionCerebral (MCAO/stroke)MaleIntragastric78 or 39 mg/kgFirst dose 2 h after MCAO

Model: Middle cerebral artery occlusion with reperfusion (MCAO/R)

XQ-1H preserved motor function, reduced infarction and apoptosis, and promoted neurogenesis in the peri-infarct cortex, subventricular zone and dentate subgranular zone in a Wnt-dependent manner.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.