Hypoxia-Inducible Factor 1alpha (HIF-1alpha) Counteracts the Acute Death of Cells Transplanted into the Injured Spinal Cord.
RatSpinal cord injuryContusionFemaleIntraspinal transplantationTransplantation 7 days after contusion injury
Model: Contusion injury of the thoracic spinal cord with cell transplantation 7 days post-injury
VP16-HIF-1alpha raised HIF-alpha 5.9-fold, increased VEGF 2.2-fold and enolase 1.7-fold, and increased Schwann cell survival after transplantation by 34.3 per cent, detectable by stereology but not by in vivo imaging. Most transplanted cell death occurred before 2 to 3 days post-implantation.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.