Beneficial effects of bardoxolone methyl, an Nrf2 activator, on crush-related acute kidney injury in rats.
RatCrushLimb / muscle crushWistarMalen = 64 rats in 8 groups, n = 8 per groupIntraperitoneal10 mg/kg
Model: Crush syndrome induced by 6 h of direct compression of both hind limbs with 3.6 kg blocks per side, followed by 3 or 24 h decompression
Bardoxolone methyl reduced renal KIM-1, NGAL, TNF-alpha, TGF-beta1 and total oxidant status and increased total antioxidant status at 3 and 24 h after decompression, lowered serum creatine kinase, blood urea nitrogen and creatinine, and decreased apoptosis.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.