Radiation mitigation of the intestinal acute radiation injury in mice by 1-[(4-nitrophenyl)sulfonyl]-4-phenylpiperazine.
MouseRadiationC3HFemalen = n = 13 per group at 20 Gy (26 total) and n = 15 per group a…Subcutaneous5 mg/kg24 h after irradiation
Model: Gastrointestinal acute radiation syndrome after abdominal irradiation with 20 or 20.5 Gy
The compound improved survival and mitigated weight loss after lethal abdominal irradiation, expanded the intestinal stem cell pool and increased regenerating crypt numbers, acting as a Smoothened agonist.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.