Platelet-rich plasma activates AKT signaling to promote wound healing in a mouse model of radiation-induced skin injury.
MouseRadiationIntradermal injection100 microlitres of platelet-rich plasma per injury siteAfter irradiation
Model: Radiation-induced dorsal skin injury from 40 Gy local irradiation delivered at 2 Gy/min (with HaCaT keratinocytes irradiated at 5 Gy in vitro)
Platelet-rich plasma healed acutely irradiated desquamated skin, activated AKT signalling with improved keratin 14 cell migration and proliferation, increased involucrin expression and reduced transepidermal water loss, indicating a strengthened cutaneous barrier.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.