Prothymosin alpha and its mimetic hexapeptide improve delayed tissue plasminogen activator-induced brain damage following cerebral ischemia.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6MaleProTalpha co-administered with tissue plasminogen activator at 4.5 h, or given…
Model: Middle cerebral artery occlusion and photochemically induced thrombosis, with delayed tissue plasminogen activator administration
Co-administration of ProTalpha or P6Q abolished haemorrhage induced by tissue plasminogen activator given at 4.5 h, reversed vascular damage and matrix metalloproteinase upregulation at 6 h, and improved motor function and survival beyond 7 days with the two-dose schedules.
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