Effect of Protease Inhibitors in Healing of the Vaginal Wall.
RatWoundSprague-DawleyFemaleLocal application at the time of surgeryAt the time of surgery
Model: Surgical injury of the vaginal wall, including ovariectomised animals
Actinonin significantly abrogated injury-induced degradation of fibulin-5 and rescued the negative effects of injury on biomechanics, histomorphology and elastic fibres. Oestrogen did not alter acute fibulin-5 loss at 12 to 48 h but rescued poor recovery at 7 days in ovariectomised animals.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.