Inhibition of neuronal ferroptosis in the acute phase of intracerebral hemorrhage shows long-term cerebroprotective effects.

Inhibition of neuronal ferroptosis in the acute phase of intracerebral hemorrhage shows long-term cerebroprotective effects.

Model: Intracerebral haemorrhage, with in vitro models and human brain tissue comparison

Iron and malondialdehyde rose by 3 h and COX-2 increased from 12 h peaking at 3 days, colocalising with NeuN. Ferrostatin-1 reduced neurological deficits, memory impairment and brain atrophy, indicating a long-term cerebroprotective effect of acute ferroptosis inhibition.

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