Hepatoprotective effect of hydromethanolic leaf extract of (Urticaceae) on carbon tetrachloride-induced liver injury and oxidative stress.
RatChemical/toxinWistar albinoBoth (3 males and 3 females per group)n = n = 6 per group; 36 rats total, plus n = 3 per dose in the…Oral70.7, 141.4 or 282.8 mg/kg (1/20, 1/10 and 1/5 of an LD50 o…Pretreatment for 7 days before carbon tetrachloride challenge
Model: Carbon tetrachloride in liquid paraffin (1:1), 1 mL/kg body weight intraperitoneally on day 7, 1 h after the final treatment dose
Doses of 70.7 and 141.4 mg/kg reduced transaminases, alkaline phosphatase and bilirubin and raised total protein; only 141.4 mg/kg improved antioxidant markers, and 282.8 mg/kg was ineffective, indicating a dose-specific effect.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.