Neuroprotection by nicotinamide mononucleotide adenylyltransferase 1 with involvement of autophagy in an aged rat model of transient cerebral ischemia and reperfusion.

Neuroprotection by nicotinamide mononucleotide adenylyltransferase 1 with involvement of autophagy in an aged rat model of transient cerebral ischemia and reperfusion.

Model: Transient focal cerebral ischaemia induced by middle cerebral artery occlusion with reperfusion; in vitro oxygen-glucose deprivation in cultured cortical neurons

Knockdown of NMNAT1 significantly increased infarct volume while lentiviral overexpression reduced ischaemia-induced cerebral injury in aged rats. Overexpression increased autophagy, reduced mTOR phosphorylation and raised SIRT1. The protection was partly abolished by the autophagy inhibitor 3-meth…

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