Effect of PI3K/PKB signal pathway inhibitor wortmannin pretreatment on intestinal barrier function in severe acute pancreatitic rats.
RatChemical/toxinSprague-Dawleyn = 18 rats per group across three groupsPretreatment before induction of severe acute pancreatitis
Model: Severe acute pancreatitis induced by retrograde pancreatic duct injection of 5% sodium taurocholate, with associated intestinal barrier injury
Wortmannin pretreatment reduced ultrastructural intestinal mucosal damage and gave lower pancreas scores (7.4 plus or minus 1.14, 10.2 plus or minus 1.48 and 12.0 plus or minus 1.58 at 3, 6 and 12 h). Plasma endotoxin and Evans blue content were significantly lower at all timepoints, and phosphoryl…
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