RORalpha suppresses interleukin-6-mediated hepatic acute phase response.
MouseChemical/toxinC57BL/6NMaleOral gavage20 mg/kg/day in 0.5% carboxymethyl cellulosePretreatment for 3 days before diethylnitrosamine injection
Model: Acute liver injury and hepatic acute-phase response induced by a single intraperitoneal injection of diethylnitrosamine 100 mg/kg
JC1-40 reduced diethylnitrosamine-induced serum transaminases, TNF-alpha and IL-1beta without changing serum IL-6, attenuated periportal apoptosis and DNA damage, and reduced leucocyte infiltration. Hepatic acute-phase gene expression fell by 35 to 45%, with lower phosphorylated STAT3 and reduced I…
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