Schisandra chinensis acidic polysaccharide partialy reverses acetaminophen-induced liver injury in mice.
MouseChemical/toxinICRMale
Model: Severe acute liver injury induced by acetaminophen (paracetamol)
SCAP significantly lowered serum ALT, AST, TNF-alpha and IL-1beta, alleviated hepatic pathological change, reduced malondialdehyde and glutathione depletion, lowered the Bax/Bcl-2 ratio, suppressed cleaved caspase-3 and raised p-AMPK, p-Akt, p-GSK-3beta, Nrf2 and HO-1 in liver tissue.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.