Depletion of Microglia Attenuates Dendritic Spine Loss and Neuronal Apoptosis in the Acute Stage of Moderate Traumatic Brain Injury in Mice.
MouseTBIFluid percussionthy-1 GFPMaleGiven for 21 consecutive days before injury
Model: Moderate lateral fluid percussion injury
Microglial depletion with PLX3397 reduced resident microglia and infiltrating immune cells, promoted neurite outgrowth, preserved dendritic spines and lowered neuronal apoptosis and endoplasmic reticulum stress markers at 1 and 3 days after injury.
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