PRECLINICAL PUBLICATION · 2019

Macrophages Educated with Exosomes from Primed Mesenchymal Stem Cells Treat Acute Radiation Syndrome by Promoting Hematopoietic Recovery.

Mouse / Radiation

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Human macrophages educated with exosomes from lipopolysaccharide-primed mesenchymal stem cells (LPS-high exosome educated macrophages)

PMID 31394269 ↗2019Reported benefit

Macrophages Educated with Exosomes from Primed Mesenchymal Stem Cells Treat Acute Radiation Syndrome by Promoting Hematopoietic Recovery.

MouseRadiationNOD.Cg (NSG)Male and femaleIntravenous (tail vein)1 x 10^6 cells per injectionApproximately 4 hours after irradiation

Model: Acute radiation syndrome induced by lethal total body irradiation

LPS-high exosome educated macrophages extended survival after lethal irradiation, reduced clinical signs of radiation injury and restored haematopoietic tissue in bone marrow and spleen relative to all other cell treatments.

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.