The Involvement of SDF-1alpha/CXCR4 Axis in Radiation-Induced Acute Injury and Fibrosis of Skin.
MixedRadiationSubcutaneous injection
Model: Localised skin irradiation, with mice receiving a 35 Gy dose, producing acute skin injury and subsequent fibrosis
Subcutaneous AMD3100 attenuated radiation-induced skin injury and fibrosis in rats, and keratinocyte-specific CXCR4 deletion reduced skin damage in mice, consistent with SDF-1alpha/CXCR4 driving profibrotic TGF-beta/Smad signalling.
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