A Surgical Mouse Model for Advancing Laryngeal Nerve Regeneration Strategies.
MouseCrushPeripheral-nerve crushC57BL/6Jn = 10 per transection group (bilateral recurrent laryngeal ner…Electrical stimulation via electrodes applied to the cervical vagus nerveIntraoperatively, immediately after recurrent laryngeal nerve crush injury
Model: Surgical transection of the recurrent laryngeal nerve or superior laryngeal nerve (unilateral or bilateral), and unilateral recurrent laryngeal nerve crush injury
Unilateral recurrent laryngeal nerve transection produced chronic vocal fold immobility with only acute dysphagia, and mice given intraoperative vagal nerve stimulation after crush injury showed accelerated and improved vocal fold recovery.
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