Protective effects of dimethyl itaconate in mice acute cardiotoxicity induced by doxorubicin.
MouseChemical/toxinC57BL/6 wild-type and Nrf2 knockoutMale
Model: Acute cardiotoxicity induced by doxorubicin administration
Dimethyl itaconate reduced doxorubicin induced cardiac injury, lowered RIP3 and oxidative stress markers, halved reactive oxygen species and limited mitochondrial damage, and these benefits were lost in Nrf2 knockout mice.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.