Perivascular CD73 cells attenuate inflammation and interstitial fibrosis in the kidney microenvironment.
MouseIschaemia-reperfusionRenal
Model: Unilateral kidney ischaemia-reperfusion injury, or folic acid nephropathy induced by folic acid 250 mg/kg, evaluated 14 days after injury
Deletion of CD73 from kidney perivascular cells increased collagen deposition, proinflammatory and macrophage marker expression and PDGFR-beta immunoreactivity at 14 days after unilateral ischaemia-reperfusion injury or folic acid treatment. Kidney dysfunction and fibrosis were rescued by administr…
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