An evaluation of the effect of bortezomib on radiation-induced urinary bladder dysfunction.
MouseRadiationC3H (per MeSH terms: Mice, Inbred C3H)Female (per MeSH terms)Subcutaneous injection0.02 mg/mlDaily injections between days 0 to 15 or days 15 to 30 after irradiation, in se…
Model: Radiation-induced urinary bladder dysfunction in an established mouse bladder model, with single graded radiation doses in five dose groups; early dysfunction occurs in two phases during the first month after irradiation (phase I days 0 to 15, phase II days 16 to 30)
Daily bortezomib between days 0 and 15 significantly decreased the number of responders during phase I of radiation-induced bladder dysfunction. Daily bortezomib between days 16 and 30 had no significant effect. The authors conclude that the two waves of acute radiation-induced bladder dysfunction…
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