PRECLINICAL PUBLICATION · 2019

The Matrine Derivate MASM Inhibits Recruitment of Gr1hi Monocyte and Alleviates Liver Injury.

Mouse / Chemical/toxin

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

MASM ((6aS,10S,11aR,11bR,11cS)-10-methylaminododecahydro-3a,7a-diaza-benzo(de)anthracene-8-thione), a matrine derivative

PMID 31357205 ↗2019Reported benefit

The Matrine Derivate MASM Inhibits Recruitment of Gr1hi Monocyte and Alleviates Liver Injury.

MouseChemical/toxinC57BL/6Male

Model: Acute and chronic liver injury induced by intraperitoneal carbon tetrachloride (CCl4) injection

MASM markedly reduced CCl4-induced acute liver injury and fibrosis on biochemical and histological assessment. The benefit was associated with lower Gr1hi monocyte infiltration into the liver and with reduced hepatic MCP-1 production and chemotactic activity.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.