Accelerated wound healing in diabetes by reprogramming the macrophages with particle-induced clustering of the mannose receptors.

Accelerated wound healing in diabetes by reprogramming the macrophages with particle-induced clustering of the mannose receptors.

Model: Full-thickness excisional skin wound in diabetic mice and in healthy mice

Wounds treated with KSiNPs closed considerably faster and showed greater collagen deposition, less inflammation and more angiogenesis in both diabetic and healthy mice. The effect was attributed to mannose receptor clustering that converted macrophages to an M2-like, pro-repair phenotype.

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