Curdione Ameliorated Doxorubicin-Induced Cardiotoxicity Through Suppressing Oxidative Stress and Activating Nrf2/HO-1 Pathway.
RatChemical/toxin
Model: Doxorubicin-induced cardiotoxicity, studied in cardiomyocytes in vitro and in rats in vivo
Curdione reduced doxorubicin-induced growth inhibition and lactate dehydrogenase release in a concentration-dependent manner and lessened histopathological cardiac damage and rises in serum creatine kinase-MB. It also limited apoptosis and reactive oxygen species accumulation, preserved mitochondri…
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