Netrin-1 Dampens Hypobaric Hypoxia-Induced Lung Injury in Mice.
MouseOtherC57BL/6Tail vein injectionPretreatment before the 18-hour decompression exposure
Model: Hypobaric hypoxia-induced lung injury produced by exposure to hypobaric stress at 340 mmHg for 30 minutes followed by 260 mmHg for 6, 12, 18 or 24 hours, with 18 hours selected as the injury exposure
Eighteen hours of hypobaric hypoxia produced the greatest bronchoalveolar protein leakage together with neutrophil infiltration, septal thickening, oedema and activation of the intrinsic apoptosis pathway. Netrin-1 pretreatment reduced protein leakage, inhibited neutrophil migration, lowered the in…
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