Local Immunomodulation Using an Adhesive Hydrogel Loaded with miRNA-Laden Nanoparticles Promotes Wound Healing.
MouseWoundCD-1Malen = n = 6 wounds per group harvested at each time point on days…Topical application of the hydrogel precursor onto the wound followed by photocrosslinking with visible light for 4 minutesHydrogels loaded with 5.0% (w/w) nanoparticles to gelatin m…Applied on day 0 immediately after the wounds were created
Model: Bilateral 6 mm full-thickness excisional dorsal skin wounds created with a biopsy punch and immobilised with sutured silicone splints
In vitro the miR-223 mimic hydrogel raised the Arg1/iNOS2 ratio about sevenfold at 24 h and reduced TNF-alpha, IL-6 and IL-1beta in M1-induced macrophages. In vivo a single application gave 95.8% wound closure by day 12 versus 66.7% for negative control miRNA, 60.8% for plain hydrogel and 44.9% for…
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