PebbleAtlas
PEBBLE / ATLAS
Open research access
PRECLINICAL PUBLICATION · 2019

A peptide from Testudo horsfieldii tortoise spleen as a potential helper for reducing acute radiation syndrome.

Mouse / Radiation

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 31313444 ↗2019Reported benefit

A peptide from Testudo horsfieldii tortoise spleen as a potential helper for reducing acute radiation syndrome.

MouseRadiationDescribed as active at very low concentrations; exact dose…

Model: Acute radiation syndrome induced by lethal doses of whole-body irradiation, with survival assessed at 30 days

Crude tortoise spleen extract significantly increased survival of mice given lethal irradiation, and iterative chromatographic purification with bioassay screening identified the tetrapeptide FTGN as the active component. FTGN accelerated repopulation of irradiated bone marrow at very low concentra…

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.