Heat-killed Salmonella typhimurium mitigated radiation-induced lung injury.
MouseRadiationC57BL/6FemaleGiven after irradiation as a mitigator rather than a pre-exposure radioprotector
Model: Radiation-induced lung injury following irradiation, with early inflammatory phase and later fibrotic phase assessed at 7 to 14 weeks
Heat-killed Salmonella typhimurium reduced lung hyperaemia and histopathological damage in the early inflammatory phase after irradiation and lowered collagen deposition in the later phase from 7 to 14 weeks. It also inhibited radiation-induced apoptosis and epithelial-mesenchymal transition in lun…
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