The effects of human immunoglobulin G on enhancing tissue protection and neurobehavioral recovery after traumatic cervical spinal cord injury are mediated through the neurovascular unit.
RatSpinal cord injuryContusionWistarFemalen = 124 female adult Wistar rats in total: 52 for molecular and…Intravenous bolusSingle intravenous bolus of hIgG at 0.02, 0.2, 0.4, 1 or 2…15 minutes after spinal cord injury
Model: Moderate-severe clip compression-contusion cervical spinal cord injury using a 35 g modified aneurysm clip applied extradurally at the C7-T1 level for 60 seconds
A single intravenous bolus of hIgG at 2 g/kg given 15 min after cervical clip compression injury increased tight junction protein expression, lowered active MMP-9, reduced neutrophil infiltration and myeloperoxidase activity, and improved functional blood flow while reducing acute lesion volume. Th…
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