Intravascular innate immune cells reprogrammed via intravenous nanoparticles to promote functional recovery after spinal cord injury.
MouseSpinal cord injuryUnspecifiedC57BL/6FemaleIntravenous
Model: Traumatic spinal cord injury with an implanted multichannel bridge
Nanoparticle treatment reduced innate immune cell accumulation at the injury four-fold and fibrotic and gliotic scarring three-fold, shifted macrophages towards proregenerative phenotypes, increased regenerating axons and myelination (about 40% of axons myelinated), and improved locomotor score to…
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