Activation of Hypoxia-Inducible Factor-1alpha Via Succinate Dehydrogenase Pathway During Acute Lung Injury Induced by Trauma/Hemorrhagic Shock.

Activation of Hypoxia-Inducible Factor-1alpha Via Succinate Dehydrogenase Pathway During Acute Lung Injury Induced by Trauma/Hemorrhagic Shock.

Model: Trauma and haemorrhagic shock induced acute lung injury, with mesenteric lymph from trauma/haemorrhagic shock applied to cells in vitro

HIF-1alpha was activated and succinate dehydrogenase inhibited in the lung during trauma and haemorrhagic shock induced acute lung injury. Pharmacological inhibition of HIF-1alpha attenuated lung inflammation and pulmonary oedema, indicating that HIF-1alpha activation is detrimental in this model.

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