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← Studies/PMID 31234659
PRECLINICAL PUBLICATION · 2019

(-)-Epicatechin mitigates radiation-induced intestinal injury and promotes intestinal regeneration via suppressing oxidative stress.

Mouse / Radiation

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Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 31234659 ↗2019Reported benefit

(-)-Epicatechin mitigates radiation-induced intestinal injury and promotes intestinal regeneration via suppressing oxidative stress.

MouseRadiationC57BL/6 and Lgr5-EGFP-IRES-creERT2Male

Model: Ionising radiation-induced intestinal epithelial injury, with an injured intestinal organoid (minigut) model

Epicatechin suppressed oxidative stress, reduced crypt cell apoptosis, enhanced Lgr5 stem cell activity and promoted intestinal epithelial regeneration after irradiation via Nrf2 and Wnt/beta-catenin signalling.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.