Stabilization of Hypoxia Inducible Factor-1alpha by Dimethyloxalylglycine Promotes Recovery from Acute Spinal Cord Injury by Inhibiting Neural Apoptosis and Enhancing Axon Regeneration.

Stabilization of Hypoxia Inducible Factor-1alpha by Dimethyloxalylglycine Promotes Recovery from Acute Spinal Cord Injury by Inhibiting Neural Apoptosis and Enhancing Axon Regeneration.

Model: Acute traumatic spinal cord injury

DMOG raised HIF-1alpha expression, reduced apoptotic protein expression, enhanced axonal regeneration through microtubule stabilisation and improved functional recovery; the benefit was abolished by inhibition of HIF-1alpha or autophagy.

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