Physical impacts of PLGA scaffolding on hMSCs: Recovery neurobiology insight for implant design to treat spinal cord injury.
RatSpinal cord injuryHemisection / partialSprague-DawleyFemaleTransplantation into the lesion epicentreImplanted at the time of acute hemisection injury
Model: Acute T9-10 segmental hemisection spinal cord injury
Only soft PLGA-scaffolded human mesenchymal stromal cells improved sensorimotor function, reduced neuroinflammation and protected tissue, whereas hard-rigidity PLGA drove mesoderm differentiation with ectopic bone, cartilage and muscle markers in neural parenchyma.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.