Xin-Ji-Er-Kang ameliorates kidney injury following myocardial infarction by inhibiting oxidative stress via Nrf2/HO-1 pathway in rats.
RatIschaemia-reperfusionCardiacSprague-Dawleyn = 138 Sprague-Dawley rats in total; control n=8, sham, myocar…Started after myocardial infarction
Model: Surgical myocardial infarction with secondary kidney injury
Xin-Ji-Er-Kang improved renal hypertrophy index, blood urea nitrogen and cystatin C, limited scar formation and improved cardiac function, sustained Nrf2 nuclear translocation and HO-1 expression, and lowered oxidative stress and renin-angiotensin-aldosterone markers relative to untreated infarctio…
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