PRECLINICAL PUBLICATION · 2019

Exosomes from human-bone-marrow-derived mesenchymal stem cells protect against renal ischemia/reperfusion injury via transferring miR-199a-3p.

Mouse / Ischaemia-reperfusion

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Exosomes from human bone-marrow-derived mesenchymal stem cells (hBMSC-Exos), enriched in miR-199a-3p

PMID 31180587 ↗2019Reported benefit

Exosomes from human-bone-marrow-derived mesenchymal stem cells protect against renal ischemia/reperfusion injury via transferring miR-199a-3p.

MouseIschaemia-reperfusionRenalBALB/cInjection, specific route not stated

Model: Renal ischaemia/reperfusion injury in mice, with in vitro hypoxia/reoxygenation in HK-2 renal tubular cells

hBMSC-derived exosomes induced functional recovery and histological protection after renal ischaemia/reperfusion and reduced cleaved caspase-3 and Sema3A, an effect attributed to transfer of miR-199a-3p.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.62. Machine-extracted fields require source verification.