Synergistic protection of matrine and lycopene against lipopolysaccharide-induced acute lung injury in mice
MouseEndotoxin/LPSBALB/cMalen = 36 male BALB/c mice randomised to 6 groups: control, 6 h li…Oral administration for matrine and lycopene; intraperitoneal injection for dexamethasone; intratracheal instillation for lipopolysaccharideMatrine 25 mg/kg and lycopene 100 mg/kg, given alone or in…Pretreatment given for 7 consecutive days before injury, with the final dose 30…
Model: Acute lung injury induced by intratracheal instillation of Escherichia coli 055:B5 lipopolysaccharide at 5 mg/kg, with tissue harvested 6 h later; control mice received intratracheal saline
Combined matrine and lycopene significantly reduced the lipopolysaccharide-induced rise in lung wet-to-dry weight ratio and attenuated haemorrhage, alveolar wall thickening, alveolar collapse and inflammatory infiltration, with a Q value of 1.27 for the lung injury score indicating synergy. The com…
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