Complement Inhibition Attenuates Early Erythrolysis in the Hematoma and Brain Injury in Aged Rats.
RatHaemorrhage/shockUnspecifiedFischer 344Malen = 109 aged rats used in total with 12 excluded (97 analysed).…Intracerebral, co-injected into the right basal ganglia with the autologous bloodN-acetylheparin 10 micrograms in 5 microlitres saline; auri…Given at the time of haemorrhage induction, co-injected with the blood
Model: Intracerebral haemorrhage induced by stereotaxic injection of 100 microlitres of autologous blood into the right basal ganglia (0.2 mm anterior, 5.5 mm ventral, 3.5 mm lateral to bregma) at 10 microlitres/min
Both complement inhibitors reduced early erythrolysis within the clot. N-acetylheparin lowered erythrolysis at day 1 (14.3+/-6.4% versus 20.9+/-6.1%, p<0.01) and day 3 (21.4+/-7.4% versus 30.9+/-8.7%, p<0.01), reduced perihaematomal iron at day 1 (24.1+/-9.7% versus 49.0+/-13.2%, p<0.01), reduced H…
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.