Vagus nerve stimulation protects against acute liver injury induced by renal ischemia reperfusion via antioxidant stress and anti-inflammation.
RatIschaemia-reperfusionRenalSprague-DawleyMalen = 18 rats in total, divided equally into three groups (6 per…Direct electrical stimulation of the left cervical vagus nerveApplied concurrently with renal ischaemia and reperfusion
Model: Remote acute liver injury induced by renal ischaemia reperfusion; right nephrectomy followed by clamping of the left renal pedicle with a non-traumatic microaneurysm clamp for 45 minutes and 6 hours of reperfusion
Renal ischaemia reperfusion severely impaired both kidney and liver function relative to sham. Vagus nerve stimulation significantly preserved kidney and liver function, decreased oxidative enzymes, apoptosis and serum and hepatic TNF-alpha and IL-6, and increased antioxidant responses compared wit…
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