Lipoxin A4 reduces hyperoxia-induced lung injury in neonatal rats through PINK1 signaling pathway
RatOtherSprague-Dawley (from PubMed MeSH indexing; not stated in the abstract)
Model: Hyperoxia-induced neonatal lung injury modelling bronchopulmonary dysplasia, produced by exposure to 85% oxygen for 7 days from birth
Lipoxin A4 significantly reduced cell and protein infiltration and oxidative stress in the lungs of hyperoxia-exposed neonatal rats, improved pulmonary function and alveolar simplification, and promoted weight gain. It inhibited TNF-alpha, MCP-1 and IL-1beta in serum and bronchoalveolar lavage flui…
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