HMGB1/RAGE pro-inflammatory axis promotes vascular endothelial cell apoptosis in limb ischemia/reperfusion injury.
RatIschaemia-reperfusionLimb / skeletal muscleSprague-DawleyMale
Model: Rat hind limb ischaemia and reperfusion with femoral artery vascular injury; parallel human umbilical vein endothelial cell hypoxia and reoxygenation model
RAGE inhibition with FPS-ZM1 significantly reduced vascular injury induced by limb ischaemia and reperfusion. It suppressed phosphorylation of p38, ERK1/2, p65 and IKBa, nuclear p65 translocation, and expression of HIF-1a, NLRP3, caspase-1, TNF-a and IL-6, although HMGB1 and RAGE expression themsel…
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