Cell non-autonomous functions of S100a4 drive fibrotic tendon healing.
MouseOtherC57BL/6J (000664); transgenic lines S100A4-GFP (012893), S100a4-TK (012902), S100a4 knockout (012904), S100a4-Cre (012641), ROSA-Ai9 (007909), Csf1r-iCre (019098)Male and femalen = RAP study n = 13 per group; S100a4 haploinsufficient versus…Intraperitoneal injectionRAP 100 ug per injection; ganciclovir 75 mg/kg; tamoxifen 1…RAP given on days 5 to 10 after surgery; ganciclovir given days 5 to 10 or days…
Model: Complete transection and surgical repair of the flexor digitorum longus tendon; complete transection and repair of the Achilles tendon in a second model
S100a4 haploinsufficiency improved tendon healing, with a 36% increase in metatarsophalangeal flexion angle (p = 0.04), a 43% decrease in gliding resistance (p = 0.028) and a 35% increase in maximum load at failure (p = 0.003); RAGE antagonist peptide gave partial benefit, improving flexion angle b…
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