Protective Effect of Thymosin beta4 against Abdominal Aortic Ischemia-Reperfusion-Induced Acute Lung Injury in Rats.
RatIschaemia-reperfusionRenalSprague-Dawleyn = 32 rats in total, n = 8 per group across four groupsIntravenous10 mg/kg, single doseOne group treated 1 h before ischaemia, a second group 15 min before reperfusion
Model: Infrarenal abdominal aorta cross-clamping with an atraumatic microvascular clamp for 90 min of ischaemia followed by 180 min of reperfusion, under pentobarbital sodium anaesthesia (60 mg/kg intraperitoneal) with midline laparotomy and heparin 50 U/kg intravenously before ischaemia
Thymosin beta 4 given either before ischaemia or before reperfusion reduced the lung wet to dry ratio (3.94 +/- 0.32 and 3.42 +/- 0.29 versus 5.44 +/- 0.27 for untreated ischaemia-reperfusion), lowered lipid hydroperoxide, malondialdehyde, pro-oxidant/antioxidant balance and pro-inflammatory cytoki…
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