Excitotoxicity Alters Endogenous Secretoneurin Plasma Levels, but Supplementation with Secretoneurin Does Not Protect Against Excitotoxic Neonatal Brain Injury.
MouseTBIUnspecifiedCD-10.25 ug/g body weight, 2.5 ug/g body weight or 12.5 ug/g bo…Single treatment 1 h after insult; acute repetitive treatment starting 1 h afte…
Model: Excitotoxic newborn brain injury induced by intracranial injection of ibotenic acid in mouse pups
Animals subjected to excitotoxic injury had significantly lower secretoneurin plasma concentrations at 6 and 120 h than healthy controls, but secretoneurin supplementation across single, acute repetitive and delayed repetitive regimens did not improve lesion size, apoptotic cell death, microglial a…
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