Spinal CCL1/CCR8 regulates phosphorylation of GluA1-containing AMPA receptor in postoperative pain after tibial fracture and orthopedic surgery in mice.
MouseFractureTibiaMaleIntrathecal injection
Model: Tibial fracture with orthopaedic surgery producing chronic postoperative pain
Intrathecal NASPM alleviated fracture-related postoperative pain, and central CCL1/CCR8 inhibition reduced mechanical and cold allodynia and GluA1 phosphorylation, while exogenous CCL1 facilitated acute pain behaviours and GluA1 phosphorylation in naive mice, an effect reversed by co-application of…
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