Endothelial Hypoxia-Inducible Factor-1alpha Is Required for Vascular Repair and Resolution of Inflammatory Lung Injury through Forkhead Box Protein M1.
MouseEndotoxin/LPSEndothelial cell-restricted Hif1a disruption (Hif1a/Tie2Cre) mice and wild-type littermatesLiposomal delivery; specific route not stated in available textAfter sepsis challenge, during the recovery phase; exact timing not stated in a…
Model: Polymicrobial sepsis or endotoxaemia challenge causing inflammatory lung injury and endothelial barrier dysfunction
Endothelial-restricted loss of Hif1a caused defective vascular repair, persistent inflammation, reduced endothelial cell proliferation and increased mortality after sepsis or endotoxaemia, and therapeutic restoration of endothelial Foxm1 by liposomal plasmid delivery reactivated the vascular repair…
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