MiR-92b-3p promotes neurite growth and functional recovery via the PTEN/AKT pathway in acute spinal cord injury.
RatSpinal cord injuryUnspecifiedSprague-Dawley
Model: Acute spinal cord injury model in adult rats, with parallel in vitro work in PC12 cells
miR-92b-3p was downregulated after acute spinal cord injury while PTEN increased, and overexpression of miR-92b-3p reduced PTEN, increased AKT phosphorylation and raised GAP43 and NF-200 expression in PC12 cells and in vivo, improving Basso, Beattie and Bresnahan locomotor scores; the effect was bl…
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