Blueberry Supplementation Mitigates Altered Brain Plasticity and Behavior after Traumatic Brain Injury in Rats.
RatTBIFluid percussionSprague-Dawleymalen = n = 8 per group for behaviour; n = 5-7 rats per group for p…dietary, ad libitum5% w/w blueberry powder mixed into pulverised standard rode…Started immediately after fluid percussion injury or sham surgery
Model: Lateral fluid percussion injury, moderate pulse of 2.7 atm through a 3.0 mm craniotomy 3.0 mm posterior to bregma and 6.0 mm left of midline; sham surgery without fluid pulse
Blueberry diet reversed TBI-induced Barnes maze learning and memory deficits, maintained hippocampal BDNF, pCREB and pCaMKII near sham levels and reduced 4-HNE, with no significant effect on elevated plus maze open-arm time.
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