Dipotassium Glycyrrhizate Improves Intestinal Mucosal Healing by Modulating Extracellular Matrix Remodeling Genes and Restoring Epithelial Barrier Functions.
MouseChemical/toxinC57BL/6femalen = Acute colitis: 8 mice per group across three groups; PCR ar…oral gavage8 mg/kg/day diluted in phosphate buffered saline; 300 micro…Acute experiment: given concurrently with the 7-day DSS exposure. Recovery expe…
Model: Dextran sodium sulfate colitis. Acute model: 3% DSS (36,000-50,000 Da) in drinking water for 7 days. Recovery model: 3% DSS for 5 days followed by 9 days of regular water or treatment
DPG downregulated 20 of 24 DSS-induced mucosal healing genes in acute colitis and accelerated recovery (full recovery at 72 h versus 144 h for vehicle; at 24 h weight 95 +/- 2 versus 87 +/- 1.1 per cent, colon length 7.5 +/- 0.43 versus 5.7 +/- 0.33 cm, histological score 0.9 +/- 0.2 versus 1.9 +/-…
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