Study on Umbilical Cord-Matrix Stem Cells Transplantation for Treatment of Acute Traumatic Brain Injury in Rats.
RatTBIUnspecifiedSprague-DawleyMalen = 30 male Sprague-Dawley rats randomised into 3 groupsIntraventricular injection (coordinates 0 at bregma, 1.5 mm lateral, 1.1 mm behind, 4.5 mm depth)1.5 x 10^6 cells in 25 microlitres
Model: Experimental traumatic brain injury in rats
UC-MSC transplantation alleviated hyperaemia, oedema and inflammatory infiltration after TBI and increased microvessel density, BDNF and GFAP expression, indicating reduced injury and improved vascular reconstruction.
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