Upregulated protein O-GlcNAcylation promoted functional and structural recovery of the contused spinal cord injury in rats by Thiamet-G treatment.
RatSpinal cord injuryContusionWistarFemalen = 74 rats total: sham n=22, injured control n=26, Thiamet-G n…After injury
Model: Contusive spinal cord injury
Thiamet-G raised protein O-GlcNAcylation, improved hindlimb locomotor recovery, reduced lesion size and injury severity, and inhibited microglia and macrophage infiltration and caspase-3 mediated apoptosis.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.